SCHEMBL8877657

SCHEMBL8877657

O=C(C=Cc1ccc(F)cc1)c1cccc2ccccc12

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1B1 Q16678 7/20 0.72
MAOB P27338 5/20 0.66
MAOA P21397 3/20 0.66
ALDH1A1 P00352 3/20 0.64
LMNA P02545 2/20 0.64
TP53 P04637 2/20 0.64
CYP1A1 P04798 5/20 0.60
CYP1A2 P05177 1/20 0.60
CYP3A4 P08684 1/20 0.60
CYP2D6 P10635 1/20 0.60
ABCG2 Q9UNQ0 2/20 0.55
TNFRSF1A P19438 1/20 0.54
MAPT P10636 2/20 0.53
MAPK1 P28482 2/20 0.53
KDM4E B2RXH2 1/20 0.53
MEN1 O00255 1/20 0.53
HPGD P15428 1/20 0.53
KMT2A Q03164 1/20 0.53
TUBB4A P04350 2/20 0.52
TUBB P07437 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8877653 1.00 CYP1B1 (0.72) CYP1B1MAOBMAOAALDH1A1LMNA
SCHEMBL13680424 0.92 CYP1B1 (0.68) CYP1B1MAOBMAOAALDH1A1LMNA
SCHEMBL12306185 0.88 CYP1B1 (0.63) CYP1B1MAOBMAOAALDH1A1LMNA
SCHEMBL699741 0.87 CYP1B1 (0.71) CYP1B1MAOBALDH1A1LMNATP53
SCHEMBL7913782 0.87 CYP1B1 (0.71) CYP1B1MAOBALDH1A1LMNATP53
SCHEMBL7641857 0.85 MAPT (0.66) CYP1B1MAOBALDH1A1LMNATP53
SCHEMBL14601354 0.85 MAPT (0.66) CYP1B1MAOBALDH1A1LMNATP53
SCHEMBL2754551 0.85 CYP1B1 (0.60) CYP1B1MAOBALDH1A1LMNATP53
SCHEMBL13203438 0.83 CYP1B1 (0.69) CYP1B1MAOBMAOAALDH1A1LMNA
SCHEMBL12948633 0.82 CYP1B1 (0.60) CYP1B1MAOBALDH1A1LMNATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5691322-A Quinoline and pyridine anchors for HMG-CoA reductase inhibitors E.R. SQUIBB & SONS, INC. (US) 1997-11-25 US disclosed
US-5686433-A CHOLESTEROL BIOSYNTHESIS INHIBITION E.R. SQUIBB & SONS, INC. (US) 1997-11-11 US disclosed
US-5506219-A ANTICHOLESTEROL AND ANTILIPEMIC AGENTS E. R. SQUIBB & SONS, INC. (US) 1996-04-09 US disclosed