Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL799541 | 0.77 | TSHR (0.61) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL8804344 | 0.75 | TSHR (0.48) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL9222314 | 0.75 | HDAC3 (0.46) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL10347814 | 0.75 | TSHR (0.58) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL11665761 | 0.75 | TSHR (0.65) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL5301475 | 0.75 | MEN1 (0.52) | TSHRSLC6A4HTR2ASLC6A2SLC6A3 | |
| SCHEMBL10192309 | 0.73 | TSHR (0.56) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL8192026 | 0.73 | TSHR (0.56) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL2796185 | 0.73 | TSHR (0.56) | TSHRSSTR4HDAC3HDAC1HDAC2 | |
| SCHEMBL3075392 | 0.73 | TSHR (0.56) | TSHRSSTR4HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5621010-A | ANTIHYPERCHOLESTEROLEMIA AND ANTIATHEROSCLEROSIS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0625507-A2 | Urea derivatives and their use as acat inhibitors | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1994-11-23 | — | — | EP | disclosed |