Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR2C | P28335 | 2/20 | 0.65 |
| ▸ | HTR2B | P41595 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.65 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | DRD2 | P14416 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179271 | 0.87 | HRH1 (0.67) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL2738853 | 0.80 | HRH1 (0.68) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL29390260 | 0.79 | HRH1 (1.00) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL4425 | 0.79 | HRH1 (1.00) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL29371361 | 0.79 | HRH1 (1.00) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| SCHEMBL6178576 | 0.78 | HRH1 (0.73) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL5198706 | 0.78 | HRH1 (0.97) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL4574215 | 0.78 | HRH1 (0.97) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL5200429 | 0.78 | HRH1 (0.97) | HRH1HTR2AHTR2CHTR2BMEN1 | |
| Desloratadine SCHEMBL5200118 | 0.78 | HRH1 (0.97) | HRH1HTR2AHTR2CHTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665726-A | ANTIALLERGIC, ANTIINFLAMMATORY AGENTS | SCHERING CORPORATION (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0535152-B1 | Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylene and piperazine compounds as PAF antagonists and compositions thereof. | SCHERING CORP (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5422351-A | Antiallergens; antiinflammatory agents | SCHERING CORPORATION (US) | 1995-06-06 | — | — | US | disclosed |
| EP-0396083-B1 | Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use | SCHERING CORP (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5151423-A | Antiinflammatory agents or antiallergens | SCHERING CORPORATION (US) | 1992-09-29 | — | — | US | disclosed |
| US-5089496-A | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies | SCHERING CORPORATION (US) | 1992-02-18 | — | — | US | disclosed |