SCHEMBL8879561

SCHEMBL8879561

NC(c1ccc(Cl)cc1)C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)OC(=O)C(=O)OC(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(N)c1ccc(Cl)cc1

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 6/20 0.49
RHOC P08134 6/20 0.41
RHOA P61586 6/20 0.41
CACNA1F O60840 2/20 0.41
CACNA1D Q01668 2/20 0.41
CACNA1S Q13698 2/20 0.41
CACNA1C Q13936 2/20 0.41
PPARG P37231 4/20 0.40
CLPP Q16740 1/20 0.39
CNR2 P34972 1/20 0.39
IDO1 P14902 2/20 0.38
PPARA Q07869 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8877299 0.88 TACR1 (0.49) TACR1RHOCRHOACACNA1FCACNA1D
SCHEMBL8878375 0.82 TACR1 (0.47) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911831 0.77 TACR1 (0.55) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9317465 0.73 TACR1 (0.52) TACR1RHOCRHOACACNA1FCACNA1D
SCHEMBL8879693 0.69 TACR1 (0.51) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL5792062 0.69 TACR1 (0.48) TACR1RHOCRHOACACNA1FCACNA1D
SCHEMBL8911533 0.69 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8878273 0.68 TACR1 (0.49) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8878874 0.68 TACR1 (0.48) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8962639 0.64 TACR1 (0.53) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5610183-A Phenylglycine derivatives pharmaceutical compositions containing them and their use in therapy MERCK, SHARP & DOHME LTD. (GB) 1997-03-11 US disclosed
EP-0593615-B1 AROMATIC COMPOUNDS, COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP disclosed