Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.81 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10391184 | 0.98 | CYP1A2 (0.78) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10391189 | 0.98 | CYP1A2 (0.78) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10390853 | 0.94 | CYP1A2 (0.81) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10391321 | 0.93 | CYP1A2 (0.70) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10391203 | 0.92 | CYP1A2 (0.69) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10391181 | 0.92 | CYP1A2 (0.83) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| SCHEMBL10390865 | 0.92 | CYP1A2 (0.83) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| Otenzepad SCHEMBL24305002 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| Otenzepad SCHEMBL341879 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 | |
| Otenzepad SCHEMBL29363384 | 0.90 | CYP1A2 (1.00) | CYP1A2CYP3A4CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254955-B1 | Substituted pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1992-05-27 | — | — | EP | claimed |
| US-4971966-A | BRADYCARDIAL, CARDIOVASCULAR DISORDERS | KARL THOMAE GMBH (DE) | 1990-11-20 | — | — | US | claimed |
| US-5641772-A | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation | DR. KARL THOMAE GMBH (DE) | 1997-06-24 | — | — | US | disclosed |
| US-5610155-A | ALZHEIMER'S | DR. KARL THOMAE GMBH (DE) | 1997-03-11 | — | — | US | disclosed |
| EP-0508370-B1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | THOMAE GMBH DR K (DE) | 1996-07-03 | — | — | EP | disclosed |
| EP-0508370-A1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | Dr. Karl Thomae GmbH (DE) | 1992-10-14 | — | — | EP | disclosed |
| EP-0254955-B1 | Substituted pyrido[2,3-b][1,4]benzodiazepin-6-ones, process for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1992-05-27 | — | — | EP | disclosed |
| US-4971966-A | BRADYCARDIAL, CARDIOVASCULAR DISORDERS | KARL THOMAE GMBH (DE) | 1990-11-20 | — | — | US | disclosed |