Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 9/20 | 0.81 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.81 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.81 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.81 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | DRD5 | P21918 | 1/20 | 0.65 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881033 | 0.97 | CHRM2 (0.79) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8879428 | 0.94 | CHRM2 (0.82) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8881459 | 0.92 | CHRM2 (0.89) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8878832 | 0.91 | CHRM2 (0.83) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8881358 | 0.90 | CHRM2 (0.82) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8881870 | 0.90 | CHRM2 (0.91) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL194898 | 0.90 | CHRM2 (1.00) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL29504161 | 0.90 | CHRM2 (1.00) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL8879988 | 0.90 | CHRM2 (0.85) | CHRM2CHRM1CHRM3CHRM4CHRM5 | |
| SCHEMBL9042607 | 0.89 | CHRM2 (0.77) | CHRM2CHRM1CHRM3CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641772-A | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation | DR. KARL THOMAE GMBH (DE) | 1997-06-24 | — | — | US | disclosed |
| US-5610155-A | ALZHEIMER'S | DR. KARL THOMAE GMBH (DE) | 1997-03-11 | — | — | US | disclosed |
| EP-0508370-B1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | THOMAE GMBH DR K (DE) | 1996-07-03 | — | — | EP | disclosed |
| EP-0508370-A1 | Condensed diazepinones, process for their preparation and compositions containing them for the treatment of the central nervous system and to enhance cerebral perfusion | Dr. Karl Thomae GmbH (DE) | 1992-10-14 | — | — | EP | disclosed |