SCHEMBL888337

SCHEMBL888337

O=[N+]([O-])C=C1NCCN1Cc1ccc(Cl)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 1.00
CHRNA1 P02708 3/20 0.89
CHRNA7 P36544 3/20 0.89
CHRNA3 P32297 2/20 0.89
CHRNB2 P17787 3/20 0.64
CHRNA4 P43681 3/20 0.64
ALDH1A1 P00352 2/20 0.64
CYP3A4 P08684 1/20 0.53
CYP2D6 P10635 1/20 0.53
MAPT P10636 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
RXFP1 Q9HBX9 1/20 0.53
NPSR1 Q6W5P4 1/20 0.49
CASP6 P55212 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL888508 1.00 SMN1; SMN2 (1.00) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
SCHEMBL6624321 1.00 SMN1; SMN2 (1.00) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
Hydrochloric Acid SCHEMBL9069690 0.99 SMN1; SMN2 (0.98) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
Hydrochloric Acid SCHEMBL9069692 0.99 SMN1; SMN2 (0.98) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
SCHEMBL888580 0.94 CHRNA1 (1.00) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
SCHEMBL888465 0.94 CHRNA1 (1.00) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
SCHEMBL888464 0.94 CHRNA1 (1.00) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
Hydrochloric Acid SCHEMBL10483912 0.93 CHRNA1 (0.98) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
Acetic Acid SCHEMBL10636735 0.92 SMN1; SMN2 (0.85) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2
Acetic Acid SCHEMBL10636729 0.92 SMN1; SMN2 (0.85) SMN1; SMN2CHRNA1CHRNA7CHRNA3CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118598887-A Microwave synthesis method of cycloxaprid 上海生农生化制品股份有限公司 2024-09-06 CN claimed
CN-117486899-A New synthetic method of cycloxaprid 上海生农生化制品股份有限公司 2024-02-02 CN claimed
CN-115960118-A Efficient synthesis method of cycloxaprid 上海生农生化制品股份有限公司 2023-04-14 CN claimed
CN-109369618-B Method for preparing 2-chloro-5- ((2- (nitromethylene) imidazoline-1-yl) methyl) pyridine in one pot 上海生农生化制品股份有限公司 2021-05-11 CN claimed
CN-112010873-A Synthetic method of cycloxaprid 上海生农生化制品股份有限公司 2020-12-01 CN claimed
CN-105348258-B Synthetic method of 2-chloro-5- ((2- (nitromethylene) imidazoline-1-yl) methyl) pyridine 上海生农生化制品股份有限公司 2020-10-23 CN claimed
US-20010051643-A1 Agents for preserving technical materials against insects TSUBOI SHINICHI (JP) 2001-12-13 US claimed
EP-0760811-A1 IMIDAZOLE DERIVATIVES AS HISTAMINE RECEPTOR H 3? (ANT)AGONISTS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1997-03-12 EP claimed
EP-0483052-B1 Picolinoxides CIBA GEIGY AG (CH) 1997-03-12 EP claimed
US-5547965-A TREATMENT AND PREVENTION OF SENILE, PRESENILE, AND ALZHEIMER'S DEMENTIA, AND DEPRESSION BAYER AKTIENGESELLSCHAFT (DE) 1996-08-20 US claimed
CN-1032182-C Stabilized agrochemical compositions NIHON TOKUSHU NOYAKU SEIZO KK (JP) 1996-07-03 CN claimed
EP-0679397-A2 Use of substituted amines for the treatment of cerebral insufficiencies BAYER AG (DE) 1995-11-02 EP claimed
EP-0627165-A1 Combined use of chemicals and microbials in cockroach control Bayer Corporation (US) 1994-12-07 EP claimed
EP-0431361-B1 Use of stabilizers for agrochemical compositions BAYER AGROCHEM KK (JP) 1994-02-23 EP claimed
EP-0431362-B1 Stabilized agrochemical compositions BAYER AGROCHEM KK (JP) 1993-11-03 EP claimed
EP-0511541-A1 Agents for preserving wood or composite-wood materials against insects NIHON BAYER AGROCHEM K.K. (JP) 1992-11-04 EP claimed
EP-0483647-A1 Hydrazine compounds or their salts, processes for producing them and pesticides containing them ISHIHARA SANGYO KAISHA, LTD. (JP) 1992-05-06 EP claimed
EP-0431361-A1 Use of stabilizers for agrochemical compositions NIHON BAYER AGROCHEM K.K. (JP) 1991-06-12 EP claimed
EP-0431362-A1 Stabilized agrochemical compositions NIHON BAYER AGROCHEM K.K. (JP) 1991-06-12 EP claimed
US-4678795-A 1-pyridylmethyl-2-nitromethylene-1,3-diazacycloalkane insecticides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1987-07-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010051643-A1 Agents for preserving technical materials against insects GPX1, FEN1, POT1 SMN1; SMN2 1051/4885CHRNA1 4520/4885CHRNA7 4679/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.