Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 8/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8074700 | 1.00 | KLK7 (0.42) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL9181992 | 0.83 | KLK7 (0.40) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8885564 | 0.81 | KLK7 (0.42) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8065802 | 0.81 | KLK7 (0.42) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8065381 | 0.76 | KLK7 (0.48) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8886170 | 0.76 | KLK7 (0.48) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL5891618 | 0.70 | KLK7 (0.48) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8884829 | 0.70 | KLK7 (0.48) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8886010 | 0.70 | KLK7 (0.48) | KLK7KLK5GPR119PRSS1PRSS2 | |
| SCHEMBL8886373 | 0.69 | NR1H3 (0.37) | KLK7KLK5GPR119PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686472-A | ANTICARCINOGENIC AND -TUMOR AGENTS; SIDE EFFECT REDUCTION; INHIBITION OF FARNESYLATION OF THE RAS PROTEIN | MERCK & CO., INC. (US) | 1997-11-11 | — | — | US | disclosed |