Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8842521 | 0.93 | ABCG2 (0.62) | ABCG2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL16930781 | 0.83 | ABCG2 (0.56) | ABCG2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL22377081 | 0.83 | ABCG2 (0.46) | ABCG2MEN1KMT2AMAPTIKBKB | |
| SCHEMBL4378433 | 0.81 | MEN1 (0.48) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL8365595 | 0.81 | ABCG2 (0.50) | ABCG2MEN1KMT2AGAAUSP30 | |
| SCHEMBL1741768 | 0.79 | CLK4 (0.62) | ABCG2 | |
| SCHEMBL8511483 | 0.79 | RARB (0.46) | ABCG2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL13492147 | 0.78 | ABCG2 (0.57) | ABCG2MEN1KMT2AMAPTNPC1 | |
| SCHEMBL643457 | 0.78 | ABCG2 (0.61) | ABCG2MEN1KMT2AALDH1A1 | |
| SCHEMBL30298952 | 0.78 | ABCG2 (0.47) | ABCG2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686456-A | DIARYLPYRIMIDINES | THE UNIVERSITY OF NORTH CAROLINA (US) | 1997-11-11 | — | — | US | disclosed |
| US-5627184-A | BACTERICIDES OF PYRIMIDINE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-05-06 | — | — | US | disclosed |
| US-5622955-A | ADMINISTERING 2,4-BIS-/4-GUANYLPHENYL/-PYRIMIDINE OR DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-04-22 | — | — | US | disclosed |
| US-5521189-A | PYRIMIDINE COMPOUNDS AS ANTIPROTOZOA AGENTS | THE UNIVERSITY OF NC AT CH (US) | 1996-05-28 | — | — | US | disclosed |