Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158131 | 0.91 | MAPT (0.60) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8885341 | 0.85 | PTGER1 (0.68) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9160300 | 0.85 | PTGER1 (0.56) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8886433 | 0.84 | PTGER1 (0.69) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8887918 | 0.84 | PTGER1 (0.65) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9158125 | 0.82 | MEN1 (0.61) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9187686 | 0.81 | PTGER1 (0.65) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL8888007 | 0.80 | MAPT (0.69) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9158142 | 0.79 | MAPT (0.61) | PTGER1MAPTMEN1ALDH1A1CYP1A2 | |
| SCHEMBL9190533 | 0.79 | PTGER1 (0.77) | PTGER1MAPTMEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661146-A | ANALGESICS | G.D. SEARLE & CO. (US) | 1997-08-26 | — | — | US | disclosed |
| US-5449675-A | Analgesics | G. D. SEARLE & CO. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5441950-A | Analgesics, prostaglandin E2 antagonists | G. D. SEARLE & CO. (US) | 1995-08-15 | — | — | US | disclosed |
| US-5382578-A | Anticonvulsants or antiischemic agents | G. D. SEARLE & CO. (US) | 1995-01-17 | — | — | US | disclosed |
| EP-0610303-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS AS ANALGESIC AGENTS | G.D. SEARLE & CO. (US) | 1994-08-17 | — | — | EP | disclosed |
| US-5288719-A | 2-,3-,8-and/or 10-substituted dibenzoxazepine compounds, pharmaceutical compositions and methods for treating osteoporosis | G. D. SEARLE & CO. (US) | 1994-02-22 | — | — | US | disclosed |
| US-5212169-A | Analgesics | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| WO-1993009105-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS AS ANALGESIC AGENTS | G.D. SEARLE & CO. (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0539977-A1 | SUBSTITUTED DIBENZOXAZEPINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ANALGESIC AGENTS AND PROSTAGLANDIN ANTAGONISTS | G.D. Searle & Co. (US) | 1993-05-05 | — | — | EP | disclosed |