Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 10/20 | 0.70 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.68 |
| ▸ | PDE4A | P27815 | 6/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.68 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891655 | 0.91 | PDE4B (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889614 | 0.88 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890145 | 0.86 | PDE4D (0.61) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8888686 | 0.85 | PDE4D (0.73) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8891197 | 0.85 | PDE4D (0.69) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.83 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890668 | 0.83 | PDE4D (0.57) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8890089 | 0.82 | PDE4B (0.76) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7361935 | 0.82 | PDE4B (0.94) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8889824 | 0.82 | PDE4B (0.71) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |