Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.70 |
| ▸ | PDE4A | P27815 | 5/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.70 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889648 | 0.85 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL1164280 | 0.85 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL8890135 | 0.85 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL6878175 | 0.84 | PDE4B (0.85) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL985307 | 0.84 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL8890123 | 0.83 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL8891655 | 0.83 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL8889809 | 0.83 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL987384 | 0.83 | PDE4B (0.80) | PDE4BPDE4DPDE4APDE4CCYP2B6 | |
| SCHEMBL7336155 | 0.83 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |