SCHEMBL8889586

SCHEMBL8889586

COC=C(C(=O)O)c1cccc2ccc(CBr)cc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1C2 P52895 1/20 0.43
MTNR1A P48039 1/20 0.38
CYP1A2 P05177 2/20 0.37
CYP2D6 P10635 2/20 0.37
CYP2C19 P33261 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
PTPN1 P18031 1/20 0.35
CNR2 P34972 3/20 0.35
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
AKR1B1 P15121 1/20 0.34
CYP4F2 P78329 2/20 0.33
CYP4A11 Q02928 2/20 0.33
PLA2G2D Q9UNK4 1/20 0.33
POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8889571 1.00 AKR1C2 (0.43) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8889580 0.87 AKR1C2 (0.41) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8533289 0.83 AKR1C2 (0.45) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8533283 0.83 AKR1C2 (0.45) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8598938 0.82 AKR1C2 (0.46) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8598935 0.82 AKR1C2 (0.46) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8891576 0.82 AKR1C2 (0.46) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8891560 0.82 AKR1C2 (0.46) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19
SCHEMBL8972816 0.80 AKR1C2 (0.58) AKR1C2CYP1A2CYP2D6CYP2C19CYP3A4
SCHEMBL8973400 0.79 AKR1C2 (0.45) AKR1C2MTNR1ACYP1A2CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997007099-A1 ALPHA-METHOXYMETHYLENE OR ALPHA-METHOXYIMINO NAPHTHYLACETIC ACID DERIVATIVES AND THEIR USE AS FUNGICIDES AGREVO UK LIMITED (GB) 1997-02-27 WO disclosed