SCHEMBL8890695

SCHEMBL8890695

CCS(=O)(=O)c1ccc(Nc2nc(NC)c3ccccc3n2)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 3/20 0.51
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 1/20 0.47
TP53 P04637 1/20 0.47
PKM P14618 1/20 0.47
RAB9A P51151 1/20 0.47
MERTK Q12866 1/20 0.45
NPY5R Q15761 1/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
MAPT P10636 1/20 0.43
HTT P42858 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8890337 0.99 SLC2A1 (0.50) SLC2A1SMN1; SMN2NPC1TP53PKM
SCHEMBL8890351 0.85 PDE5A (0.59) SLC2A1PKM
Hydrochloric Acid SCHEMBL8889234 0.84 PDE5A (0.58) SLC2A1SMN1; SMN2PKMKDM4EALDH1A1
Hydrochloric Acid SCHEMBL9776771 0.77 SLC2A1 (0.77) SLC2A1SMN1; SMN2NPC1PKMRAB9A
SCHEMBL8891834 0.76 SLC2A1 (0.44) SLC2A1
Hydrochloric Acid SCHEMBL8889266 0.75 SLC2A1 (0.46) SLC2A1
SCHEMBL8891393 0.74 SLC2A1 (0.45) SLC2A1SMN1; SMN2NPC1TP53PKM
Hydrochloric Acid SCHEMBL8890271 0.74 SLC2A1 (0.47) SLC2A1SMN1; SMN2NPC1TP53PKM
SCHEMBL20459506 0.72 GAA (0.41) SMN1; SMN2NPC1TP53PKMRAB9A
SCHEMBL8891020 0.70 PDE5A (0.40) MERTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO claimed