Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 11/20 | 0.68 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.46 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.46 |
| ▸ | MERTK | Q12866 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8891045 | 1.00 | NPY5R (0.68) | NPY5RCTNNB1TCF7L2MERTKCDK7 | |
| SCHEMBL8891241 | 0.90 | NPY5R (0.68) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8891254 | 0.90 | NPY5R (0.68) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8892092 | 0.84 | NPY5R (0.62) | NPY5RMERTKAPPBCHEACHE | |
| SCHEMBL8892104 | 0.84 | NPY5R (0.62) | NPY5RMERTKAPPBCHEACHE | |
| SCHEMBL8890729 | 0.83 | NPY5R (0.72) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8890766 | 0.83 | NPY5R (0.72) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8891621 | 0.81 | NPY5R (1.00) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8891244 | 0.80 | NPY5R (1.00) | NPY5RCTNNB1TCF7L2MERTKAPP | |
| SCHEMBL8892081 | 0.80 | NPY5R (0.76) | NPY5RCTNNB1TCF7L2MERTKCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | claimed |