SCHEMBL8892699

SCHEMBL8892699

CC1(C)CC(OC(=O)CC#N)CC(C)(C)N1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.45
EZH2 Q15910 9/20 0.33
NPC1L1 Q9UHC9 2/20 0.32
CTSL P07711 1/20 0.32
CTSS P25774 1/20 0.32
KCNH2 Q12809 1/20 0.32
ATM Q13315 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
JAK1 P23458 3/20 0.31
JAK3 P52333 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL39117 0.80 GAA (0.51) GAANPC1L1ATML3MBTL1
SCHEMBL563911 0.80 GAA (0.51) GAAEZH2ATML3MBTL1
SCHEMBL8848439 0.79 GAA (0.50) GAAATML3MBTL1
SCHEMBL313718 0.77 GAA (0.49) GAANPC1L1ATML3MBTL1
SCHEMBL4452939 0.77 GAA (0.49) GAANPC1L1ATML3MBTL1
SCHEMBL25475319 0.77 GAA (0.49) GAANPC1L1ATML3MBTL1
SCHEMBL10079247 0.77 GAA (0.49) GAANPC1L1ATML3MBTL1
SCHEMBL315239 0.77 GAA (0.49) GAANPC1L1
SCHEMBL4430086 0.77 GAA (0.45) GAANPC1L1
SCHEMBL11354021 0.76 GAA (0.51) GAAEZH2ATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5624981-A Polyalkylpiperidine containing acetic acid and 3-amino-acrylic acid derivatives BASF AKTIENGESELLSCHAFT (DE) 1997-04-29 US disclosed
US-4452884-A 2,2,6,6-TETRAMETHYLPIPERIDIN-4-YL HYDROXYPHENYL ALKYL AMIDES OR ESTERS AS LIGHT STABILIZERS CIBA-GEIGY AG (CH) 1984-06-05 US disclosed
US-4226999-A ANTIOXIDANTS FOR POLYMERS CIBA-GEIGY CORPORATION (US) 1980-10-07 US disclosed
US-4148784-A HEAT, LIGHT AND OXIDATION RESISTANCE FOR SYNTHETIC POLYMERS CIBA-GEIGY CORPORATION (US) 1979-04-10 US disclosed