Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.34 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | PDE9A | O76083 | 2/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14789011 | 1.00 | KDM4E (0.42) | KDM4EPOLA1SLC29A1TYMPPDE9A | |
| SCHEMBL12570245 | 0.93 | KDM4E (0.41) | KDM4EPOLA1SLC29A1TYMPPDE9A | |
| SCHEMBL12762708 | 0.93 | KDM4E (0.41) | KDM4EPOLA1SLC29A1TYMPPDE9A | |
| SCHEMBL889594 | 0.84 | SLC29A1 (0.49) | SLC29A1 | |
| SCHEMBL12570243 | 0.81 | POLA1 (0.56) | KDM4EPOLA1SLC29A1 | |
| SCHEMBL889698 | 0.81 | POLA1 (0.56) | KDM4EPOLA1SLC29A1 | |
| SCHEMBL889618 | 0.80 | SLC29A1 (0.41) | SLC29A1P2RY1 | |
| SCHEMBL14789017 | 0.80 | SLC29A1 (0.41) | SLC29A1P2RY1 | |
| SCHEMBL14789009 | 0.79 | KDM4E (0.53) | KDM4EPOLA1TAS1R3TAS1R1POLB | |
| SCHEMBL889631 | 0.79 | KDM4E (0.53) | KDM4EPOLA1TAS1R3TAS1R1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8361727-B2 | 3′OH-unblocked, nucleotides and nucleosides base modified with labels and photocleavable, terminating groups and methods for their use in DNA sequencing | LASERGEN, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20110287427-A1 | 3'OH-UNBLOCKED, NUCLEOTIDES AND NUCLEOSIDES BASE MODIFIED WITH LABELS AND PHOTOCLEAVABLE, TERMINATING GROUPS AND METHODS FOR THEIR USE IN DNA SEQUENCING | LASERGEN, INC. (US) | 2011-11-24 | — | — | US | disclosed |