Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 5/20 | 0.43 |
| ▸ | CA1 | P00915 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 5/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | TYMP | P19971 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.34 |
| ▸ | NPY2R | P49146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855534 | 1.00 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| SCHEMBL367134 | 1.00 | KMT2A (0.67) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| SCHEMBL11352268 | 0.94 | KMT2A (0.64) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| SCHEMBL11379553 | 0.94 | KMT2A (0.64) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11376105 | 0.93 | KMT2A (0.63) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| Pimonidazole SCHEMBL51977 | 0.93 | KMT2A (0.63) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| Hydrochloric Acid SCHEMBL11379185 | 0.92 | KMT2A (0.62) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| Pimonidazole SCHEMBL11390660 | 0.92 | KMT2A (0.62) | KMT2ALMNATHRBCYP2C19L3MBTL1 | |
| SCHEMBL12396375 | 0.91 | KMT2A (0.78) | KMT2ALMNATHRBCYP2C19CA12 | |
| SCHEMBL11350180 | 0.91 | KMT2A (0.60) | KMT2ALMNATHRBCYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5659048-A | CHEMOSENSITIZER, RADIOSENSITIZER ADMINISTERING TO PATIENTS WHOM ARE SENSITIVE TO RADIATION OR CHEMOTHERAPY | BRITISH TECHNOLOGY GROUP LIMITED (GB) | 1997-08-19 | — | — | US | disclosed |
| US-5543527-A | ANTITUMOR AGENTS | BRITISH TECHNOLOYG GROUP LIMITED (GB) | 1996-08-06 | — | — | US | disclosed |
| US-5481000-A | RADIOSENSITIZERS OR CHEMOSENSITIZERS; PATENT CLAIMS CHIRAL 3-/2-HYDROXY-3-/2-NITROIMIDAZOL-1-YL/PROPYL/-2-OXAZOLIDINONE, HAVING /S/ CONFIGURATION AT OH CARBON AND FREE OF /R/ CONFIGURATION | WARNER-LAMBERT COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| EP-0652870-A1 | Process for preparing chiral (((2-bromoethyl)amino)methyl)-2-nitro-1H-imidazol-1- ethanol and related compounds | WARNER-LAMBERT COMPANY (US) | 1995-05-17 | — | — | EP | disclosed |
| US-5342959-A | Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds | WARNER-LAMBERT COMPANY (US) | 1994-08-30 | — | — | US | disclosed |
| WO-1994015922-A1 | NOVEL PROCESS FOR PREPARING CHIRAL [[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-1H-IMIDAZOL-1-ETHANOL AND RELATED COMPOUNDS | WARNER LAMBERT COMPANY (US) | 1994-07-21 | — | — | WO | disclosed |