Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896634 | 0.86 | DRD4 (0.51) | DRD4MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL15247183 | 0.78 | DRD4 (0.71) | DRD4SIGMAR1LMNAKDM4EMAPT | |
| SCHEMBL12385909 | 0.76 | DRD4 (0.77) | DRD4SIGMAR1LMNAKDM4EPOLB | |
| SCHEMBL4195949 | 0.75 | SLC6A2 (0.51) | CHRNA7DRD3 | |
| SCHEMBL11990246 | 0.75 | DRD4 (0.64) | DRD4MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL6031812 | 0.74 | DRD4 (1.00) | DRD4SIGMAR1KDM4EALDH1A1CHRNA7 | |
| SCHEMBL11989515 | 0.74 | DRD4 (0.62) | DRD4SIGMAR1LMNAKDM4EPOLB | |
| SCHEMBL5217502 | 0.73 | MAPT (0.57) | DRD4MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL27619095 | 0.73 | DRD4 (0.60) | DRD4MEN1KMT2ASIGMAR1LMNA | |
| SCHEMBL27619094 | 0.73 | DRD4 (0.61) | DRD4MEN1KMT2ASIGMAR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652242-A | 3-METHYL-4-(4-(4-(4-PYRIDYL)PIPERAZIN-1-YL)PHENOXY)BURYIC ACID, AMIDE OR ESTER; INHIBITORS OF BINDING OF FIBRINOGEN TO GLYCOPROTEIN | ZENECA LIMITED (GB) | 1997-07-29 | — | — | US | disclosed |