Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 13/20 | 0.60 |
| ▸ | BDKRB2 | P30411 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1855447 | 0.92 | NPC1L1 (0.70) | NPC1L1BDKRB2OPRM1OPRK1DDR1 | |
| SCHEMBL8894157 | 0.90 | NPC1L1 (0.59) | NPC1L1BDKRB2OPRM1OPRK1DDR1 | |
| SCHEMBL17140929 | 0.83 | NPC1L1 (0.65) | NPC1L1BDKRB2OPRM1OPRK1DDR1 | |
| SCHEMBL8892630 | 0.83 | NPC1L1 (0.67) | NPC1L1BDKRB2OPRM1OPRK1DDR1 | |
| SCHEMBL20187144 | 0.82 | NPC1L1 (0.66) | NPC1L1OPRM1OPRK1DDR1 | |
| SCHEMBL20187070 | 0.82 | NPC1L1 (0.66) | NPC1L1BDKRB2DDR1 | |
| SCHEMBL8893884 | 0.81 | NPC1L1 (0.56) | NPC1L1BDKRB2OPRM1OPRK1DDR1 | |
| SCHEMBL20187219 | 0.81 | NPC1L1 (0.74) | NPC1L1DDR1 | |
| SCHEMBL20187150 | 0.81 | NPC1L1 (0.64) | NPC1L1DDR1 | |
| SCHEMBL5563023 | 0.80 | NPC1L1 (0.64) | NPC1L1BDKRB2OPRM1OPRK1DDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |