Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 19/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8898172 | 0.91 | C1R (0.83) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8897820 | 0.84 | C1R (0.82) | C1R | |
| SCHEMBL7339271 | 0.83 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL6395012 | 0.82 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7339597 | 0.81 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8898767 | 0.78 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8899919 | 0.78 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8898149 | 0.77 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8897772 | 0.75 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL7333908 | 0.75 | C1R (1.00) | C1RNPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652237-A | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes | WARNER-LAMBERT COMPANY (US) | 1997-07-29 | — | — | US | disclosed |