Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GSTP1 | P09211 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17274985 | 0.84 | MAPT (0.50) | HSD17B10CYP2C19MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL24922866 | 0.83 | SIRT2 (0.47) | MAPTSMN1; SMN2GSTP1ALDH1A1SIRT2 | |
| SCHEMBL24922901 | 0.77 | NOTUM (0.44) | MAPTSMN1; SMN2GSTP1ALDH1A1SIRT2 | |
| SCHEMBL10203000 | 0.75 | SIRT2 (0.33) | CYP2C19ALDH1A1SIRT2NOTUMCYP1A2 | |
| SCHEMBL2888294 | 0.75 | MAPT (0.43) | HSD17B10CYP2C19MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL12205176 | 0.73 | SMN1; SMN2 (0.43) | HSD17B10CYP2C19MAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL24922897 | 0.73 | SIRT2 (0.42) | MAPTGSTP1SIRT2LMNANOTUM | |
| SCHEMBL6317292 | 0.72 | — | — | |
| SCHEMBL22593402 | 0.72 | — | — | |
| SCHEMBL24922905 | 0.72 | SIRT2 (0.39) | MAPTSMN1; SMN2GSTP1ALDH1A1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |