Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15705868 | 0.81 | TDP1 (0.55) | TDP1THRBMAPK1HIF1AMEN1 | |
| SCHEMBL12671027 | 0.81 | TDP1 (0.69) | TDP1THRBMAPK1HIF1AMEN1 | |
| SCHEMBL13532450 | 0.80 | TDP1 (0.71) | TDP1THRBMAPK1HIF1AMEN1 | |
| Bromide SCHEMBL25280 | 0.79 | TDP1 (0.70) | TDP1THRBMAPK1HIF1AMEN1 | |
| Zinc Chloride SCHEMBL29577877 | 0.76 | TDP1 (0.65) | TDP1THRBMAPK1HIF1AMEN1 | |
| Zinc Chloride SCHEMBL29837408 | 0.75 | TDP1 (0.64) | TDP1THRBMAPK1HIF1AMEN1 | |
| SCHEMBL16983238 | 0.67 | TDP1 (0.69) | TDP1THRBMAPK1HIF1AMEN1 | |
| SCHEMBL12331223 | 0.66 | HTT (0.48) | TDP1THRBMAPK1HIF1AMEN1 | |
| Hydrochloric Acid SCHEMBL25301058 | 0.66 | TDP1 (0.80) | TDP1THRBMAPK1HIF1AMEN1 | |
| Zinc Ion SCHEMBL29366028 | 0.66 | TDP1 (0.75) | TDP1THRBMAPK1HIF1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8465921-B2 | Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders | ELITECH HOLDING B.V. (NL) | 2013-06-18 | — | — | US | disclosed |
| US-20110275070-A1 | HYBRIDIZATION AND MISMATCH DISCRIMINATION USING OLIGONUCLEOTIDES CONJUGATED TO MINOR GROOVE BINDERS | EPOCH PHARMACEUTICALS, INC. | 2011-11-10 | — | — | US | disclosed |