⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14006552 | 0.75 | — | — | |
| SCHEMBL16864373 | 0.68 | — | — | |
| SCHEMBL34801 | 0.61 | — | — | |
| SCHEMBL10172352 | 0.61 | — | — | |
| SCHEMBL8610296 | 0.57 | — | — | |
| SCHEMBL990627 | 0.57 | — | — | |
| SCHEMBL4894778 | 0.57 | — | — | |
| Water SCHEMBL28143155 | 0.57 | — | — | |
| SCHEMBL6754664 | 0.57 | — | — | |
| Hydrochloric Acid SCHEMBL27868053 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9994853-B2 | Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference | SIRNA THERAPEUTICS, INC. (US) | 2018-06-12 | — | — | US | disclosed |
| US-20160152973-A1 | CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID MOLECULES THAT MEDIATE RNA INTERFERENCE | BANK OF AMERICA, N.A. | 2016-06-02 | — | — | US | disclosed |
| US-20110313024-A1 | RNA INTERFERENCE MEDIATED INHIBITION OF PROPROTEIN CONVERTASE SUBTILISIN KEXIN 9 (PCSK9) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) | MERCK SHARP & DOHME CORP. | 2011-12-22 | — | — | US | disclosed |
| US-20110288154-A1 | RNA Interference Mediated Inhibition of Epithelial Sodium Channel (ENaC) Gene Expression Using Short Interfering Nucleic Acid (siNA) | MERCK & CO., INC. | 2011-11-24 | — | — | US | disclosed |