Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 12/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.46 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401860 | 0.85 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9127180 | 0.85 | BACE1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5401504 | 0.85 | PSEN1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7362254 | 0.84 | PSEN1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL6361258 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL623164 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL2773923 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL402508 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL31107105 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Telinavir SCHEMBL29450575 | 0.81 | CYP3A4 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614522-A | SULFONAMIDE AND UREA-CONTAINING HYDROXYETHYLAMINE COMPOUNDS | G.D. SEARLE & CO. (US) | 1997-03-25 | — | — | US | disclosed |
| US-5475027-A | Retroviral protease inhibitors | G.D. SEARLE & CO. (US) | 1995-12-12 | — | — | US | disclosed |