SCHEMBL8900385

SCHEMBL8900385

N=C1NC(=O)CN1CC(=O)O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
ACE P12821 3/20 0.35
KMT2A Q03164 3/20 0.34
CYP2D6 P10635 2/20 0.34
CYP2C19 P33261 2/20 0.34
POLB P06746 1/20 0.34
CYP2C9 P11712 1/20 0.34
EPHX2 P34913 1/20 0.33
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
ITGB3 P05106 1/20 0.31
ITGB2 P05107 1/20 0.31
ITGB1 P05556 1/20 0.31
ITGAV P06756 1/20 0.31
ITGA2B P08514 1/20 0.31
ITGA5 P08648 1/20 0.31
ITGB5 P18084 1/20 0.31
ITGAL P20701 1/20 0.31
CRBN Q96SW2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8345781 0.82 TSHR (0.39) TSHRACEKMT2ACYP2D6CYP2C19
Hydrochloric Acid SCHEMBL1371699 0.80 TSHR (0.38) TSHRACEKMT2ACYP2D6CYP2C19
SCHEMBL3419632 0.77 KMT2A (0.37) TSHRACEKMT2ACYP2D6CYP2C19
Cyclocreatine SCHEMBL9074350 0.74 CRBN (0.35) TSHRACEKMT2ACYP2D6CYP2C19
SCHEMBL5945932 0.71 PTGS1 (0.42) TSHRKMT2APOLBLMNAITGB3
Creatinine SCHEMBL3287858 0.71 CRBN (0.50) KMT2ACYP3A4CRBNMEN1
SCHEMBL4705905 0.70 EPHX2 (0.68) KMT2APOLBEPHX2MEN1
Creatinine SCHEMBL17873936 0.70 CRBN (0.45) KMT2ACRBNMEN1
Creatinine SCHEMBL21404094 0.70 CRBN (0.45) KMT2ACYP3A4CRBNMEN1
Creatinine SCHEMBL21404062 0.70 CRBN (0.45) TSHRKMT2ALMNACRBNMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0458901-B1 INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY MASSACHUSETTS INST TECHNOLOGY (US) 1997-12-17 EP claimed
EP-0660709-A1 CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY AMIRA, INC. (US) 1995-07-05 EP claimed
WO-1993012781-A2 CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY AMIRA, INC. (US) 1993-07-08 WO claimed
JP-9104896-A None JP disclosed
EP-0458901-B1 INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY MASSACHUSETTS INST TECHNOLOGY (US) 1997-12-17 EP disclosed
JP-H09104896-A CLEANSING AGENT COMPOSITION HENKEL JAPAN KK 1997-04-22 JP disclosed
EP-0758681-A2 Inhibiting transformation of cells having elevated purine metabolic enzyme activity MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1997-02-19 EP disclosed
EP-0660709-A1 CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY AMIRA, INC. (US) 1995-07-05 EP disclosed
US-5324731-A Method of inhibiting transformation of cells in which purine metabolic enzyme activity is elevated AMIRA, INC. (US) 1994-06-28 US disclosed
EP-0557383-A1 METHOD OF INHIBITING TRANSFORMATION, GROWTH AND METASTASIS OF CELLS IN WHICH PURINE METABOLIC ENZYME ACTIVITY IS ELEVATED AMIRA, INC. (US) 1993-09-01 EP disclosed
WO-1993012781-A2 CREATINE ANALOGS HAVING ANTIVIRAL ACTIVITY AMIRA, INC. (US) 1993-07-08 WO disclosed
WO-1992008456-A2 METHOD OF INHIBITING TRANSFORMATION, GROWTH AND METASTASIS OF CELLS IN WHICH PURINE METABOLIC ENZYME ACTIVITY IS ELEVATED AMIRA, INC. (US) 1992-05-29 WO disclosed
EP-0458901-A1 INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1991-12-04 EP disclosed
WO-1990009192-A1 INHIBITING TRANSFORMATION OF CELLS HAVING ELEVATED PURINE METABOLIC ENZYME ACTIVITY MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 1990-08-23 WO disclosed