Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.62 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.62 |
| ▸ | ALOX5AP | P20292 | 10/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8922393 | 0.94 | CYSLTR2 (0.60) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8922287 | 0.94 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8923671 | 0.93 | ALOX5AP (0.59) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8925370 | 0.93 | CYSLTR2 (0.63) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8900452 | 0.92 | ALOX5AP (0.58) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8899507 | 0.91 | CYSLTR1 (0.64) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8920223 | 0.88 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8925362 | 0.85 | ALOX5AP (0.54) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8922323 | 0.82 | ALOX5AP (0.58) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 | |
| SCHEMBL8923072 | 0.82 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1ALOX5APGPBAR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691351-A | Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1997-11-25 | — | — | US | disclosed |
| WO-1997029090-A1 | BIS-(HETEROARYLMETHOXYPHENYL)CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF LEUKOTRIENE BIOSYTHESIS | ABBOTT LABORATORIES (US) | 1997-08-14 | — | — | WO | disclosed |