SCHEMBL890148

SCHEMBL890148

CC(C)(C)OC(=O)N1CCC[C@H]1c1nc(-c2ccc(-c3ccc4[nH]c([C@@H]5[C@@H]6C[C@@H](CC6(F)F)N5C(=O)OC(C)(C)C)nc4c3)cc2)c[nH]1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PRCP P42785 5/20 0.36
PTGES O14684 2/20 0.33
CHEK2 O96017 2/20 0.33
HCRTR1 O43613 3/20 0.33
HCRTR2 O43614 3/20 0.33
USP30 Q70CQ3 2/20 0.33
GPR119 Q8TDV5 1/20 0.33
UCHL1 P09936 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL889377 0.93 PRCP (0.33) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL890203 0.87 PRCP (0.36) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL889381 0.87 PRCP (0.36) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL890251 0.87 PRCP (0.37) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL10150949 0.86 PRCP (0.43) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL10150951 0.84 PRCP (0.41) PRCPPTGESHCRTR1HCRTR2
SCHEMBL889363 0.84 PREP (0.35) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL10150928 0.83 PRCP (0.39) PRCPPTGESCHEK2HCRTR1HCRTR2
SCHEMBL22361591 0.82 HCRTR1 (0.42) PRCPCHEK2HCRTR1HCRTR2
SCHEMBL10121382 0.82 HCRTR1 (0.42) PRCPCHEK2HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110064698-A1 HEPATITIS C VIRUS INHIBITORS ENANTA PHARMACEUTICALS, INC. 2011-03-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110064698-A1 HEPATITIS C VIRUS INHIBITORS HAVCR2, EIF2AK2, SLC10A1 PRCP 289/4885PTGES 1672/4885CHEK2 4338/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.