SCHEMBL8901888

SCHEMBL8901888

COc1cccc(Nc2nc(Nc3ccccc3)c3cc([N+](=O)[O-])ccc3n2)c1

nearest known ligand 0.76

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 16/20 0.76
PIN1 Q13526 4/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8899114 0.99 ABCG2 (0.75) ABCG2PIN1
SCHEMBL8900921 0.82 ABCG2 (0.66) ABCG2PIN1
SCHEMBL8891851 0.82 NPY5R (0.78) ABCG2
Hydrochloric Acid SCHEMBL8899915 0.81 ABCG2 (0.64) ABCG2PIN1
SCHEMBL19129462 0.81 ABCG2 (0.67) ABCG2
Hydrochloric Acid SCHEMBL8899399 0.81 NPY5R (0.76) ABCG2
SCHEMBL8889167 0.81 NPY5R (0.76) ABCG2
SCHEMBL8899361 0.80 ABCG2 (0.67) ABCG2
Hydrochloric Acid SCHEMBL8907425 0.80 HTT (0.75) ABCG2
Hydrochloric Acid SCHEMBL8901559 0.79 ABCG2 (0.65) ABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997020822-A1 QUINAZOLIN-2,4-DIAZIRINES AS NPY RECEPTOR ANTAGONIST NOVARTIS AG (CH) 1997-06-12 WO claimed