Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.78 |
| ▸ | MERTK | Q12866 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL890393 | 1.00 | PIK3CD (0.78) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL890627 | 1.00 | PIK3CD (0.78) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL890586 | 0.86 | PIK3CD (0.78) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL890526 | 0.86 | PIK3CD (0.78) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL890373 | 0.86 | PIK3CD (0.78) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL890498 | 0.85 | PIK3CD (0.78) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL890598 | 0.85 | PIK3CD (0.78) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL890728 | 0.85 | PIK3CD (0.78) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL975287 | 0.84 | PIK3CD (0.72) | PIK3CDMERTKPIK3R1AXLPIK3CB | |
| SCHEMBL974613 | 0.83 | PIK3CD (0.71) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-8754089-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-05 | — | — | US | disclosed |
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-05 | — | — | US | disclosed |
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2012-04-05 | — | — | US | disclosed |
| WO-2010151735-A2 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2010-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120083502-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | MCL1, MALT1, BCL9 | PIK3CD 24/4885MERTK 698/4885PIK3R1 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.