Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17321195 | 1.00 | GAA (0.51) | GAAUSP2EPHX2RIPK1MMP12 | |
| SCHEMBL1561585 | 0.91 | GAA (0.51) | GAAUSP2EPHX2RIPK1TSHR | |
| SCHEMBL1561583 | 0.91 | GAA (0.51) | GAAUSP2EPHX2RIPK1TSHR | |
| SCHEMBL17321198 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL1562200 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL1561671 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL1561668 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL30157031 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL1562206 | 0.88 | GAA (0.50) | GAAEPHX2RIPK1 | |
| SCHEMBL17324441 | 0.87 | GAA (0.49) | GAAEPHX2RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5618808-A | Benzothiazepine and benzoxazepine derivatives as cholecystokinin receptor antagonists | PFIZER, INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0648213-A1 | BENZOTHIAZEPINE AND BENZOXAZEPINE DERIVATIVES AS CHOLECYSTOKININ RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1995-04-19 | — | — | EP | disclosed |