Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 13/20 | 0.67 |
| ▸ | SRD5A1 | P18405 | 5/20 | 0.66 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902462 | 1.00 | SRD5A2 (0.67) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL23752478 | 0.92 | SRD5A2 (0.68) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL21068049 | 0.92 | SRD5A2 (0.68) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL2488075 | 0.92 | SRD5A2 (0.68) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8163286 | 0.92 | SRD5A2 (0.68) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL29655549 | 0.92 | SRD5A2 (0.70) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8163428 | 0.92 | SRD5A2 (0.70) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8163423 | 0.92 | SRD5A2 (0.70) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8904222 | 0.90 | SRD5A2 (0.56) | SRD5A2SRD5A1ESR1ARESR2 | |
| SCHEMBL8158983 | 0.89 | SRD5A2 (0.65) | SRD5A2SRD5A1ESR1ARESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5683995-A | 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | claimed |
| EP-0673251-A4 | — | — | 1995-10-25 | — | — | EP | claimed |
| EP-0673251-A1 | 17 SUBSTITUTED ACYL-3-CARBOXY 3,5-DIENE STEROIDALS AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-27 | — | — | EP | claimed |
| WO-1994011004-A1 | 17 SUBSTITUTED ACYL-3-CARBOXY 3,5-DIENE STEROIDALS AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-26 | — | — | WO | claimed |
| US-5683995-A | 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0673251-A4 | — | — | 1995-10-25 | — | — | EP | disclosed |
| EP-0673251-A1 | 17 SUBSTITUTED ACYL-3-CARBOXY 3,5-DIENE STEROIDALS AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994011004-A1 | 17 SUBSTITUTED ACYL-3-CARBOXY 3,5-DIENE STEROIDALS AS 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-26 | — | — | WO | disclosed |