SCHEMBL8905253

SCHEMBL8905253

c1ccc(P(c2ccccc2)C2CCC2P(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
SLC18A3 Q16572 1/20 0.36
SIGMAR1 Q99720 1/20 0.36
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
TSHR P16473 1/20 0.35
MAOA P21397 6/20 0.33
MAOB P27338 6/20 0.33
KDM1A O60341 4/20 0.33
CYP2C19 P33261 4/20 0.33
CYP2B6 P20813 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2D6 P10635 2/20 0.33
CYP2C9 P11712 2/20 0.33
ESR1 P03372 1/20 0.33
ESR2 Q92731 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11423113 1.00 CYP3A4 (0.43) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL7523503 0.90 CYP3A4 (0.39) CYP3A4TDP1CHRNB2CHRNB4CHRNA3
SCHEMBL3676137 0.90 CYP3A4 (0.39) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL11043908 0.90 CYP3A4 (0.39) CYP3A4TDP1CHRNB2CHRNB4CHRNA3
SCHEMBL3680204 0.90 CYP3A4 (0.39) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL7523506 0.90 CYP3A4 (0.39) CYP3A4TDP1CHRNB2CHRNB4CHRNA3
SCHEMBL7527097 0.90 CYP3A4 (0.39) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL7522233 0.90 CYP3A4 (0.39) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL3674735 0.90 CYP3A4 (0.39) CYP3A4TDP1SLC18A3SIGMAR1CHRNB2
SCHEMBL7523498 0.90 CYP3A4 (0.39) CYP3A4TDP1CHRNB2CHRNB4CHRNA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9266806-B1 Reductive carbonylation of methanol to acetaldehyde EASTMAN CHEMICAL COMPANY (US) 2016-02-23 US claimed
US-4221744-A Hydroformylation process employing rhodium-based catalysts comprising ligands having electronegative substituents CELANESE CORPORATION (US) 1980-09-09 US claimed
JP-62012787-A None JP disclosed
US-9266806-B1 Reductive carbonylation of methanol to acetaldehyde EASTMAN CHEMICAL COMPANY (US) 2016-02-23 US disclosed
US-5637779-A CONDENSATING ETHYNYL-B-IONOL WITH AN ACETAL IN PRESENCE OF A COPPER CATALYST AND A BASE; HYDROGENATING; FORMING RETINOL;REDUCTION RHONE-POULENC NUTRITION ANIMALE (FR) 1997-06-10 US disclosed
JP-S6212787-A NOVEL 1,2-BIS-DIPHENYLPHOSPHINE DERIVATIVE IHARA CHEM IND CO LTD 1987-01-21 JP disclosed