Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 2/20 | 0.33 |
| ▸ | SI | P14410 | 2/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25589779 | 1.00 | CA1 (0.39) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL23970203 | 1.00 | CA1 (0.39) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL25589781 | 1.00 | CA1 (0.39) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL23970227 | 1.00 | CA1 (0.39) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL14017850 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL21309834 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL25590418 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL21916643 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL104103 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 | |
| SCHEMBL13741733 | 0.98 | CA1 (0.40) | CA1CA2CA4PIM1ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |