Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167547 | 0.85 | TAAR1 (0.74) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL224150 | 0.82 | TAAR1 (0.70) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL1751436 | 0.82 | TAAR1 (1.00) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL18638548 | 0.82 | TAAR1 (0.70) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL4652086 | 0.82 | TAAR1 (1.00) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL24879174 | 0.82 | TAAR1 (0.70) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL4651929 | 0.79 | TAAR1 (0.76) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL12310233 | 0.79 | TAAR1 (0.66) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL17626174 | 0.79 | TAAR1 (0.66) | TAAR1RAB9ANPC1POLBPTPN1 | |
| SCHEMBL1750312 | 0.79 | TAAR1 (0.76) | TAAR1RAB9ANPC1POLBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |