Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 7/20 | 0.44 |
| ▸ | NPY1R | P25929 | 5/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | NPY2R | P49146 | 4/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.37 |
| ▸ | OTC | P00480 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.35 |
| ▸ | RRM1 | P23921 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172217 | 0.98 | NPY4R (0.45) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| SCHEMBL42488 | 0.98 | NPY4R (0.45) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| SCHEMBL157856 | 0.98 | NPY4R (0.45) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Urea SCHEMBL6812514 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL866931 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| SCHEMBL2236129 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL940539 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL2762373 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL940540 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R | |
| Hydrochloric Acid SCHEMBL29027297 | 0.97 | NPY4R (0.44) | NPY4RNPY1RDPP7NPY2RNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597897-A | POLYMER MATRIX MADE FROM LACTIC ACID AND/OR GLYCOLIC ACID FOR SEQUESTERING PROTEINS | GENETICS INSTITUTE, INC. (US) | 1997-01-28 | — | — | US | disclosed |