Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 4/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | NPC1 | O15118 | 1/20 | 1.00 |
| ▸ | ADORA1 | P30542 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (S)-Pia SCHEMBL2506660 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL25566839 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (R)-Pia SCHEMBL29389146 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL25566844 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL25566838 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL122932 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL14829806 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL6762494 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| (S)-Pia SCHEMBL29616978 | 1.00 | ADORA2A (1.00) | ADORA2AADORA2BADORA3TP53CYP3A4 | |
| SCHEMBL10601202 | 0.92 | ADORA2A (0.85) | ADORA2AADORA2BADORA3TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5683989-A | TREATMENT OF CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-11-04 | — | — | US | disclosed |
| US-5589467-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1996-12-31 | — | — | US | disclosed |
| EP-0689405-A4 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5484774-A | 2, N6 -disubstituted adenosines, tri-O-ester derivatives and their pharmaceutical compositions to treat ischemias | NOVO NORDISK A/S (DK) | 1996-01-16 | — | — | US | disclosed |
| EP-0689405-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021195-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1994-09-29 | — | — | WO | disclosed |