Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.60 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17728182 | 0.84 | MAPK14 (0.64) | MAPK14CSNK1DMAPK11 | |
| SCHEMBL16060785 | 0.80 | MAPK14 (0.65) | MAPK14CSNK1DMAPK11SMN1; SMN2 | |
| SCHEMBL16092216 | 0.79 | MAPK14 (0.65) | MAPK14CSNK1DMAPK11SOAT1SMN1; SMN2 | |
| SCHEMBL1753203 | 0.79 | SOAT1 (0.59) | MAPK14CSNK1DMAPK11SOAT1SMN1; SMN2 | |
| SCHEMBL1752998 | 0.79 | SOAT1 (0.59) | MAPK14CSNK1DMAPK11SOAT1SMN1; SMN2 | |
| SCHEMBL1753077 | 0.78 | SOAT1 (0.58) | MAPK14CSNK1DMAPK11SOAT1 | |
| SCHEMBL1753173 | 0.78 | SOAT1 (0.58) | MAPK14CSNK1DMAPK11SOAT1 | |
| SCHEMBL16092108 | 0.77 | PDE3B (0.42) | MAPK14 | |
| SCHEMBL1753214 | 0.76 | SOAT1 (0.50) | MAPK14CSNK1DMAPK11SOAT1 | |
| SCHEMBL1599078 | 0.76 | SOAT1 (0.50) | MAPK14CSNK1DMAPK11SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188096-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188096-B2 | Protein kinase targeted therapeutics | NORTHWESTERN UNIVERSITY (US) | 2012-05-29 | — | — | US | disclosed |