Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 18/20 | 0.42 |
| ▸ | PPARA | Q07869 | 12/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827684 | 0.90 | PPARG (0.38) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL6052101 | 0.83 | PPARG (0.61) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9411863 | 0.83 | PPARG (0.47) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL8458527 | 0.82 | FFAR1 (0.54) | PPARGCYP3A4HRH3 | |
| SCHEMBL9829240 | 0.81 | PPARG (0.37) | PPARGPPARAPPARDHRH3 | |
| SCHEMBL9411875 | 0.81 | PPARG (0.47) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9828026 | 0.80 | PPARG (0.40) | PPARGPPARACYP3A4PPARDHRH3 | |
| SCHEMBL9411826 | 0.80 | PPARG (0.43) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9411839 | 0.80 | PPARG (0.43) | PPARGPPARACYP2C9CYP3A4KCNH2 | |
| SCHEMBL9828248 | 0.79 | MAOB (0.50) | PPARGPPARACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0208420-B1 | THIAZOLIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | claimed |
| US-4775687-A | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-10-04 | — | — | US | claimed |
| US-5594015-A | Thiazolidine derivatives for the treatment of psoriasis | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0208420-B1 | THIAZOLIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1991-09-18 | — | — | EP | disclosed |
| US-4775687-A | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1988-10-04 | — | — | US | disclosed |
| EP-0208420-A1 | Thiazolidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1987-01-14 | — | — | EP | disclosed |