Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydantoin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | MB | P02144 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PYGB | P11216 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydantoin SCHEMBL8909092 | 1.00 | CRBN (0.41) | CRBNMBLMNAKDM4ECYP2C19 | |
| Hydantoin SCHEMBL599570 | 0.88 | CRBN (0.42) | CRBNMBPYGBKMT2A | |
| Hydantoin SCHEMBL2136148 | 0.88 | CRBN (0.42) | CRBNMBLMNAKDM4ECYP2C19 | |
| Hydantoin SCHEMBL28545807 | 0.86 | CRBN (0.41) | CRBNMBLMNAKDM4ECYP2C19 | |
| Hydantoin SCHEMBL9798274 | 0.85 | — | — | |
| Hydantoin SCHEMBL27705088 | 0.84 | CRBN (0.52) | CRBNMBALDH1A1PDE3BPDE3A | |
| Hydantoin SCHEMBL27690 | 0.84 | — | — | |
| Hydantoin SCHEMBL7285865 | 0.84 | — | — | |
| Hydantoin SCHEMBL10636755 | 0.83 | CRBN (0.42) | CRBNMBLMNAPDE3BPDE3A | |
| Hydantoin SCHEMBL27932488 | 0.83 | CRBN (0.35) | CRBNMB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4102867-A | DISPERSE DYEABILITY | AKZONA INCORPORATED (US) | 1978-07-25 | — | — | US | claimed |
| EP-3092276-B1 | MAGENTA INKS | HEWLETT PACKARD DEVELOPMENT CO (US) | 2021-11-24 | — | — | EP | disclosed |
| CN-107410304-B | Compositions comprising benzyl alcohol derivatives and other antimicrobially active compounds | 西姆莱斯有限公司 | 2020-06-12 | — | — | CN | disclosed |
| US-10414930-B2 | Magenta inks | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2019-09-17 | — | — | US | disclosed |
| US-20170022383-A1 | MAGENTA INKS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2017-01-26 | — | — | US | disclosed |
| EP-3092276-A1 | MAGENTA INKS | Hewlett-Packard Development Company, L.P. (US) | 2016-11-16 | — | — | EP | disclosed |
| CN-105899625-A | Magenta ink | 惠普发展公司，有限责任合伙企业 | 2016-08-24 | — | — | CN | disclosed |
| WO-2015105503-A1 | MAGENTA INKS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2015-07-16 | — | — | WO | disclosed |
| US-5693107-A | INTERNAL COMBUSTION ENGINE INTAKE VALVE ANTIDEPOSIT AGENT | SHELL OIL COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| US-5489315-A | ANTIDEPOSITS AGENTS | SHELL OIL COMPANY (US) | 1996-02-06 | — | — | US | disclosed |
| US-4102867-A | DISPERSE DYEABILITY | AKZONA INCORPORATED (US) | 1978-07-25 | — | — | US | disclosed |
| US-4102867-A | DISPERSE DYEABILITY | AKZONA INCORPORATED (US) | 1978-07-25 | — | — | US | disclosed |