Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611009 | 0.89 | CHRM1 (0.65) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6915862 | 0.87 | CHRM1 (0.68) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Fumaric Acid SCHEMBL7614556 | 0.81 | CHRM1 (0.58) | CHRM1 | |
| Fumaric Acid SCHEMBL7614546 | 0.81 | CHRM1 (0.58) | CHRM1 | |
| Fumaric Acid SCHEMBL7617777 | 0.80 | CHRM1 (0.59) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| Fumaric Acid SCHEMBL7617772 | 0.80 | CHRM1 (0.59) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6912861 | 0.80 | CHRM1 (0.78) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL23370722 | 0.80 | CHRM4 (0.69) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6917561 | 0.78 | CHRM4 (0.74) | CHRM1CHRM4CHRM2CHRM5CHRM3 | |
| SCHEMBL6913814 | 0.78 | CHRM1 (0.82) | CHRM1CHRM4CHRM2CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544756-B1 | 1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINES, THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-05 | — | — | EP | claimed |
| EP-0544756-A1 | 1,2,5,6-TETRAHYDRO-1-METHYLPYRIDINES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1993-06-09 | — | — | EP | claimed |
| WO-1992003430-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-03-05 | — | — | WO | claimed |