Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.47 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | FCER2 | P06734 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | FPR1 | P21462 | 4/20 | 0.41 |
| ▸ | FPR2 | P25090 | 4/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | SDCBP | O00560 | 1/20 | 0.41 |
| ▸ | SDC2 | P34741 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910738 | 0.89 | MEN1 (0.45) | MEN1KMT2ASSTR3FKBP4MMP1 | |
| SCHEMBL3218655 | 0.87 | KMT2A (0.68) | MEN1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL6243605 | 0.84 | SSTR3 (0.56) | MEN1KMT2ASSTR3FKBP4MMP1 | |
| SCHEMBL5079966 | 0.83 | KMT2A (0.66) | MEN1KMT2AALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL14050095 | 0.81 | FKBP4 (0.60) | MEN1KMT2ASSTR3FKBP4MMP1 | |
| SCHEMBL7355900 | 0.80 | TACR1 (0.51) | FKBP4 | |
| SCHEMBL14050124 | 0.80 | FKBP4 (0.57) | MEN1KMT2ASSTR3FKBP4MMP1 | |
| SCHEMBL29740041 | 0.80 | SSTR3 (0.59) | MEN1KMT2ASSTR3MMP1FCER2 | |
| SCHEMBL10440798 | 0.79 | SSTR3 (0.56) | MEN1KMT2ASSTR3MMP1FCER2 | |
| SCHEMBL5943202 | 0.78 | SSTR3 (0.45) | MEN1KMT2ASSTR3FKBP4MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652136-A | ENZYME MUTANT WHERE CATALYTIC FUNCTIONALITY HAS BEEN MODIFIED OR REPLACED, MUTANT WILL HAVE PREFERENCE FOR SUBSTRATES SUPPLYING THE MODIFIED OR REPLACED CATALYTIC FUNCTIONAL GROUP | GENENCOR INTERNATIONAL, INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5472855-A | Genetic engineering forming an enzyme mutants | GENENTECH, INC. (US) | 1995-12-05 | — | — | US | disclosed |
| US-5371008-A | Catalytically active enzyme-substrate complex comprising a subtilisin-related protease variant in contact with first substrate containing a first selected region | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5371190-A | Enzyme assisted catalysis | GENENCOR INTERNATIONAL, INC. (US) | 1994-12-06 | — | — | US | disclosed |