Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.67 |
| ▸ | PRKCI | P41743 | 1/20 | 0.51 |
| ▸ | BID | P55957 | 3/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.50 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | CTSG | P08311 | 1/20 | 0.50 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28002759 | 0.94 | IAPP (0.66) | IAPPPRKCIBIDMCL1BCL2L1 | |
| SCHEMBL68921 | 0.92 | IAPP (0.65) | IAPPPRKCIELANECTSG | |
| Toluene SCHEMBL27530782 | 0.92 | IAPP (0.58) | IAPPPRKCIBIDMCL1BCL2L1 | |
| SCHEMBL27438781 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| SCHEMBL28032839 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| Water SCHEMBL27676525 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| Methyl Alcohol SCHEMBL27475042 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| SCHEMBL27848644 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| Bromide SCHEMBL27499802 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG | |
| SCHEMBL27397030 | 0.90 | IAPP (0.62) | IAPPPRKCIELANECTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681669-A | ORGANIC SOLVENT CONTAINING AN AROMATIC CARBONATE AND DISSOLVED LITHIUM SALT | UBE INDUSTRIES, LTD. (JP) | 1997-10-28 | — | — | US | disclosed |