Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 2/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | MPL | P40238 | 2/20 | 0.53 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | MAP2 | P11137 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 3/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87518 | 0.89 | MPL (0.57) | PIM3PIM1MPLPBRM1APP | |
| SCHEMBL29516203 | 0.89 | MPL (0.57) | PIM3PIM1MPLPBRM1APP | |
| SCHEMBL28176383 | 0.80 | MPL (0.47) | MPLKDM4EKIF11ALDH1A1JAK2 | |
| SCHEMBL28165763 | 0.80 | PIM3 (0.55) | PIM3PIM1MPLAPPMAP2 | |
| SCHEMBL8389062 | 0.78 | MPL (0.56) | PIM3PIM1MPLPBRM1APP | |
| SCHEMBL28176388 | 0.78 | MPL (0.56) | PIM3PIM1MPLPBRM1APP | |
| SCHEMBL28045184 | 0.78 | MPL (0.59) | PIM3PIM1MPLPBRM1APP | |
| SCHEMBL28181009 | 0.78 | PIM3 (0.59) | PIM3PIM1MPLPBRM1MAP2 | |
| SCHEMBL29862697 | 0.77 | PIM3 (0.49) | PIM3PIM1MPLAPPMAP2 | |
| SCHEMBL29844370 | 0.77 | PBRM1 (0.78) | PIM3PIM1MPLPBRM1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243046-A | Acylguanidine derivatives or salts thereof | ASTELLAS PHARMA INC (JP) | 2008-08-13 | — | — | CN | disclosed |
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |