Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.72 |
| ▸ | HTR2C | P28335 | 1/20 | 0.72 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9404423 | 1.00 | ADORA1 (0.72) | ADORA1ADORA3ADORA2AHTR2CADORA2B | |
| SCHEMBL8909506 | 0.88 | ADORA1 (0.81) | ADORA1ADORA3ADORA2AADORA2BTP53 | |
| SCHEMBL9404515 | 0.88 | ADORA1 (0.81) | ADORA1ADORA3ADORA2AADORA2BTP53 | |
| SCHEMBL6835028 | 0.88 | ADORA1 (0.73) | ADORA1ADORA3ADORA2AHTR2CADORA2B | |
| SCHEMBL6835023 | 0.88 | ADORA1 (0.73) | ADORA1ADORA3ADORA2AHTR2CADORA2B | |
| SCHEMBL3847115 | 0.86 | ADORA1 (0.68) | ADORA1ADORA3ADORA2AHTR2C | |
| SCHEMBL9404414 | 0.86 | ADORA1 (0.68) | ADORA1ADORA3ADORA2AHTR2C | |
| SCHEMBL8908854 | 0.86 | ADORA1 (0.73) | ADORA1ADORA3ADORA2AADORA2BTP53 | |
| SCHEMBL3847109 | 0.86 | ADORA1 (0.68) | ADORA1ADORA3ADORA2AHTR2C | |
| SCHEMBL8909117 | 0.86 | ADORA1 (0.68) | ADORA1ADORA3ADORA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603348-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1994-06-29 | — | — | EP | claimed |
| WO-1993023418-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-11-25 | — | — | WO | claimed |
| US-5672588-A | Purine derivatives | NOVO NORDISK A/S (DK) | 1997-09-30 | — | — | US | disclosed |
| EP-0603348-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1994-06-29 | — | — | EP | disclosed |
| WO-1993023418-A1 | PURINE DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-11-25 | — | — | WO | disclosed |