Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895509 | 1.00 | CYP1A2 (0.64) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL14478507 | 1.00 | CYP1A2 (0.64) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL14478483 | 0.83 | CYP1A2 (0.61) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL9814683 | 0.83 | CYP1A2 (0.57) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL9814684 | 0.83 | CYP1A2 (0.57) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| E-5110 SCHEMBL5323330 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL9814650 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL14479539 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| SCHEMBL9814646 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 | |
| E-5110 SCHEMBL677921 | 0.82 | CYP1A2 (0.59) | CYP1A2CYP2C9ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-61257967-A | — | — | None | — | — | JP | disclosed |
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| EP-0691129-A2 | Thiazolidone and pyrrolidinone compounds for inhibiting bone loss | ELI LILLY AND COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| EP-0204964-B1 | 2-PYRROLIDONE DERIVATIVES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL COMPOSITION AND USE | Eisai Co., Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4833160-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | EISAI CO., LTD. (JP) | 1989-05-23 | — | — | US | disclosed |
| EP-0204964-A1 | 2-Pyrrolidone derivatives, process for preparing them, pharmaceutical composition and use | Eisai Co., Ltd. (JP) | 1986-12-17 | — | — | EP | disclosed |
| JP-S61257967-A | 2-PYRROLIDONE DERIVATIVE | EISAI CO LTD | 1986-11-15 | — | — | JP | disclosed |