⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20311013 | 1.00 | — | — | |
| SCHEMBL20282958 | 1.00 | — | — | |
| SCHEMBL2902379 | 0.84 | — | — | |
| SCHEMBL2237799 | 0.82 | — | — | |
| SCHEMBL16142831 | 0.82 | — | — | |
| SCHEMBL26694738 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL1409661 | 0.79 | DPP4 (0.35) | — | |
| SCHEMBL24954889 | 0.76 | — | — | |
| SCHEMBL20690906 | 0.74 | AGL (0.34) | — | |
| SCHEMBL8331861 | 0.72 | AGL (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3860975-B1 | MODULATORS OF HEMOGLOBIN FOR THE TREATMENT OF SICKLE CELL DISEASE | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-10-18 | — | — | EP | disclosed |
| EP-3860975-A1 | MODULATORS OF HEMOGLOBIN FOR THE TREATMENT OF SICKLE CELL DISEASE | Global Blood Therapeutics, Inc. (US) | 2021-08-11 | — | — | EP | disclosed |
| US-11014884-B2 | Modulators of hemoglobin | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-05-25 | — | — | US | disclosed |
| US-20200140384-A1 | MODULATORS OF HEMOGLOBIN | GLOBAL BLOOD THERAPEUTICS, INC. | 2020-05-07 | — | — | US | disclosed |
| WO-2020072377-A1 | MODULATORS OF HEMOGLOBIN FOR THE TREATMENT OF SICKLE CELL DISEASE | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2020-04-09 | — | — | WO | disclosed |
| EP-2794596-B1 | SUBSTITUTED BENZYLPYRAZOLES | BAYER IP GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| US-5646126-A | ANTITUMOR AGENTS EFFECTIVE AGAINST MULTIPLE DRUG RESISTANT CELL LINES | EPOCH PHARMACEUTICALS | 1997-07-08 | — | — | US | disclosed |
| EP-0748331-A1 | MODIFIED OLIGONUCLEOTIDE DUPLEXES HAVING ANTICANCER ACTIVITY | EPOCH PHARMACEUTICALS, INC. (US) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995023162-A1 | MODIFIED OLIGONUCLEOTIDE DUPLEXES HAVING ANTICANCER ACTIVITY | MICROPROBE CORPORATION (US) | 1995-08-31 | — | — | WO | disclosed |