Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.77 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.77 |
| ▸ | USP2 | O75604 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.53 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.53 |
| ▸ | EIF4A2 | Q14240 | 1/20 | 0.53 |
| ▸ | EBP | Q15125 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8504695 | 1.00 | KDM4E (0.77) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| SCHEMBL8770526 | 1.00 | KDM4E (0.77) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| SCHEMBL29634911 | 0.90 | KDM4E (0.65) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL15335258 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL21548986 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL24239067 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL12504599 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL22766044 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL12946605 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA | |
| Tigogenin SCHEMBL12793576 | 0.87 | KDM4E (1.00) | KDM4ESLCO1B3SLCO1B1USP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703052-A | HYPOCHOLESTEROLEMIC AGENTS | PFIZER INC. (US) | 1997-12-30 | — | — | US | disclosed |