SCHEMBL8911255

SCHEMBL8911255

O=CNCNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(c1ccccc1)c1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.69
CACNA1F O60840 4/20 0.69
CACNA1D Q01668 4/20 0.69
CACNA1S Q13698 4/20 0.69
CACNA1C Q13936 4/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8965330 1.00 TACR1 (0.69) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9564932 0.91 TACR1 (0.57) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827093 0.83 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8827091 0.83 TACR1 (0.80) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8912893 0.83 TACR1 (0.84) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911081 0.83 TACR1 (0.64) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8912110 0.83 TACR1 (0.78) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8965847 0.83 TACR1 (0.60) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8911166 0.82 TACR1 (0.71) TACR1CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL8910667 0.82 TACR1 (0.71) TACR1CACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP claimed
WO-1993001160-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO claimed
EP-0522808-A2 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy MERCK SHARP & DOHME LTD. (GB) 1993-01-13 EP claimed
US-5629347-A TACHYKININ ANTAGONIST USED IN TREATMENT OF INFLAMMATION, MIGRAINE, POSTHERPETIC NEURALGIA MERCK SHARP & DOHME LTD. (GB) 1997-05-13 US disclosed
US-5494926-A ANTIINFLAMMATORY AGENT, ANTIARTHRITIC AGENT; TREATING PAIN, HEADACHE MERCK SHARP & DOHME LTD. (GB) 1996-02-27 US disclosed
EP-0593557-B1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME (GB) 1996-01-31 EP disclosed
EP-0593557-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY. MERCK SHARP & DOHME (GB) 1994-04-27 EP disclosed
WO-1993024465-A1 2/3-(HETEROCYCLIC ALKYL AMINO)-1-(SUBST.-PHENYL-METHOXY)-ETHANES/PROPANES AS TACHYKININ-RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 1993-12-09 WO disclosed
WO-1993001160-A1 AROMATIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY MERCK SHARP & DOHME LIMITED (GB) 1993-01-21 WO disclosed