SCHEMBL8911583

SCHEMBL8911583

c1ccc2c(-c3ccnnc3-c3ccnc4ccccc34)ccnc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.46
TGFBR1 P36897 4/20 0.45
MAPK14 Q16539 3/20 0.45
RAB9A P51151 3/20 0.45
NPC1 O15118 2/20 0.45
ALDH1A1 P00352 2/20 0.45
MAPK1 P28482 2/20 0.45
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
HSD17B10 Q99714 1/20 0.45
BMP4 P12644 2/20 0.44
NFATC1 O95644 1/20 0.44
DYRK1A Q13627 1/20 0.44
NCF1 P14598 1/20 0.44
GRM4 Q14833 3/20 0.43
TGFBR2 P37173 1/20 0.43
ABL2 P42684 1/20 0.43
CSNK1A1 P48729 1/20 0.43
CSNK1D P48730 1/20 0.43
MAP3K20 Q9NYL2 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27917128 0.82 CYP1A2 (0.60) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL29699887 0.82 CYP1A2 (0.60) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL1227713 0.82 CYP1A2 (0.60) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL30487734 0.80 CYP1A2 (0.58) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL8911588 0.79 CYP1A2 (0.53) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL10481631 0.76 MAPK11 (0.44) TGFBR1MAPK14RAB9ANPC1ALDH1A1
SCHEMBL4499365 0.76 CYP1A2 (0.54) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL8719155 0.75 HTR2C (0.61) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL7918743 0.75 MAPT (0.56) CYP1A2TGFBR1MAPK14RAB9ANPC1
SCHEMBL20873070 0.73 CYP1A2 (0.56) CYP1A2TGFBR1MAPK14RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0765313-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F. HOFFMANN-LA ROCHE AG (CH) 1997-04-02 EP disclosed
WO-1995035287-A1 N,N'-BIS(QUINOLIN-4-YL)-DIAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMALARIALS F.HOFFMANN-LA ROCHE AG (CH) 1995-12-28 WO disclosed